Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that drive cancer progression and metastasis. Using a...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: González, Nazareno, Cardama, Georgina A., Chinestrad, Patricio, Robles-Valero, Javier, Rodríguez-Fdez, Sonia, Lorenzo-Martín, L. Francisco, Bustelo, Xosé R., Lorenzano Menna, Pablo, Gomez, Daniel E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174510/
https://ncbi.nlm.nih.gov/pubmed/32351958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00240
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