Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines

Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity of ZINC69391 and 1A-116, two chemically-related Rac1 pharmacological inhibitors,...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cabrera, Maia, Echeverria, Emiliana, Lenicov, Federico Remes, Cardama, Georgina, Gonzalez, Nazareno, Davio, Carlos, Fernández, Natalia, Menna, Pablo Lorenzano
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716746/
https://ncbi.nlm.nih.gov/pubmed/29228706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21533
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