Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity, plays a key role in the invasive phenotype o...

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Podrobná bibliografie
Vydáno v:Onco Targets Ther
Hlavní autoři: Cardama, Georgina A, Gonzalez, Nazareno, Ciarlantini, Matias, Gandolfi Donadío, Lucia, Comin, María Julieta, Alonso, Daniel F, Menna, Pablo Lorenzano, Gomez, Daniel E
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218912/
https://ncbi.nlm.nih.gov/pubmed/25378937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S67998
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