Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity

In the last years, the development of new drugs in oncology has evolved notably. In particular, drug development has shifted from empirical screening of active cytotoxic compounds to molecularly targeted drugs blocking specific biologic pathways that drive cancer progression and metastasis. Using a...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: González, Nazareno, Cardama, Georgina A., Chinestrad, Patricio, Robles-Valero, Javier, Rodríguez-Fdez, Sonia, Lorenzo-Martín, L. Francisco, Bustelo, Xosé R., Lorenzano Menna, Pablo, Gomez, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7174510/
https://ncbi.nlm.nih.gov/pubmed/32351958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00240
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