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De Novo Purine Biosynthesis Is Required for Intracellular Growth of Staphylococcus aureus and for the Hypervirulence Phenotype of a purR Mutant

Staphylococcus aureus is a noted human and animal pathogen. Despite decades of research on this important bacterium, there are still many unanswered questions regarding the pathogenic mechanisms it uses to infect the mammalian host. This can be attributed to it possessing a plethora of virulence fac...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Goncheva, Mariya I., Flannagan, Ronald S., Heinrichs, David E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171247/
https://ncbi.nlm.nih.gov/pubmed/32094249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00104-20
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