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Identification of tetranectin-targeting monoclonal antibodies to treat potentially lethal sepsis.

For the clinical management of sepsis, antibody-based strategies have only been attempted to antagonize pro-inflammatory cytokines, but not yet been tried to target harmless proteins that may interact with these pathogenic mediators. Here we report an antibody strategy to intervene in the harmful in...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Chen, Weiqiang, Qiang, Xiaoling, Wang, Yongjun, Zhu, Shu, Li, Jianhua, Babaev, Ariella, Yang, Huan, Gong, Jonathan, Becker, Lance, Wang, Ping, Tracey, Kevin J., Wang, Haichao
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7169984/
https://ncbi.nlm.nih.gov/pubmed/32295901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaz3833
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