Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis

We have recently reported an important role of Connexin 43 (Cx43) hemichannels in the pathogenesis of lethal sepsis through facilitating ATP efflux to potentiate the double-stranded RNA-activated protein kinase R (PKR)-dependent macrophage activation. Here we further elucidated the possible role of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Weiqiang, Zhu, Shu, Wang, Yongjun, Li, Jianhua, Qiang, Xiaoling, Zhao, Xiaoling, Yang, Huan, D’Angelo, John, Becker, Lance, Wang, Ping, Tracey, Kevin J., Wang, Haichao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336828/
https://ncbi.nlm.nih.gov/pubmed/30655582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37232-z
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