Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA

Background and Aim:  We have reported previously that synthetic small interfering RNA (siRNA) and DNA‐based siRNA expression vectors efficiently and specifically suppress hepatitis C virus (HCV) replication in vitro. In this study, we investigated the effects of the siRNA targeting HCV‐RNA in vivo....

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Bibliographic Details
Published in:J Gastroenterol Hepatol
Main Authors: Sakamoto, Naoya, Tanabe, Yoko, Yokota, Takanori, Satoh, Kenichi, Sekine‐Osajima, Yuko, Nakagawa, Mina, Itsui, Yasuhiro, Tasaka, Megumi, Sakurai, Yuki, Cheng‐Hsin, Chen, Yano, Masahiko, Ohkoshi, Shogo, Aoyagi, Yutaka, Maekawa, Shinya, Enomoto, Nobuyuki, Kohara, Michinori, Watanabe, Mamoru
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Asia 2007
Subjects:
Experimental Hepatology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166320/
https://ncbi.nlm.nih.gov/pubmed/17683479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1440-1746.2007.05076.x
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