Effective Suppression of Human Immunodeficiency Virus Type 1 through a Combination of Short- or Long-Hairpin RNAs Targeting Essential Sequences for Retroviral Integration

Small interfering RNA (siRNA) could provide a new therapeutic approach to treating human immunodeficiency virus type 1 (HIV-1) infection. For long-term suppression of HIV-1, emergence of siRNA escape variants must be controlled. Here, we constructed lentiviral vectors encoding short-hairpin RNAs (sh...

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Detalhes bibliográficos
Main Authors: Nishitsuji, Hironori, Kohara, Michinori, Kannagi, Mari, Masuda, Takao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563699/
https://ncbi.nlm.nih.gov/pubmed/16840344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00078-06
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