Critical Contribution of Tyr15 in the HIV-1 Integrase (IN) in Facilitating IN Assembly and Nonenzymatic Function through the IN Precursor Form with Reverse Transcriptase

Nonenzymatic roles for HIV-1 integrase (IN) at steps prior to the enzymatic integration step have been reported. To obtain structural and functional insights into the nonenzymatic roles of IN, we performed genetic analyses of HIV-1 IN, focusing on a highly conserved Tyr15 in the N-terminal domain (N...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Takahata, Tatsuro, Takeda, Eri, Tobiume, Minoru, Tokunaga, Kenzo, Yokoyama, Masaru, Huang, Yu-Lun, Hasegawa, Atsuhiko, Shioda, Tatsuo, Sato, Hironori, Kannagi, Mari, Masuda, Takao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165222/
https://ncbi.nlm.nih.gov/pubmed/27795445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02003-16
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