Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

Small interfering RNAs (siRNAs) efficiently inhibit gene expression by RNA interference. Here, we report efficient inhibition, by both synthetic and vector-derived siRNAs, of hepatitis C virus (HCV) replication, as well as viral protein synthesis, using an HCV replicon system. The siRNAs were design...

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Bibliographische Detailangaben
Hauptverfasser: Yokota, Takanori, Sakamoto, Naoya, Enomoto, Nobuyuki, Tanabe, Yoko, Miyagishi, Makoto, Maekawa, Shinya, Yi, Li, Kurosaki, Masayuki, Taira, Kazunari, Watanabe, Mamoru, Mizusawa, Hidehiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2003
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1319196/
https://ncbi.nlm.nih.gov/pubmed/12740604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor840
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