Stepwise promoter melting by bacterial RNA polymerase

Transcription initiation requires formation of the open promoter complex, RPo. To generate RPo, RNA polymerase (RNAP) unwinds the DNA duplex to form the transcription bubble and loads the DNA into the RNAP active site. RPo formation is a multi-step process with transient intermediates of unknown str...

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Udgivet i:Mol Cell
Main Authors: Chen, James, Chiu, Courtney, Gopalkrishnan, Saumya, Chen, Albert Y., Olinares, Paul Dominic B., Saecker, Ruth M., Winkelman, Jared T., Maloney, Michael F., Chait, Brian T., Ross, Wilma, Gourse, Richard L., Campbell, Elizabeth A., Darst, Seth A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7166197/
https://ncbi.nlm.nih.gov/pubmed/32160514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.02.017
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