E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

TraR and its homolog DksA are bacterial proteins that regulate transcription initiation by binding directly to RNA polymerase (RNAP) rather than to promoter DNA. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remain...

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Vydáno v:eLife
Hlavní autoři: Chen, James, Gopalkrishnan, Saumya, Chiu, Courtney, Chen, Albert Y, Campbell, Elizabeth A, Gourse, Richard L, Ross, Wilma, Darst, Seth A
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970531/
https://ncbi.nlm.nih.gov/pubmed/31841111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49375
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