E. coli TraR allosterically regulates transcription initiation by altering RNA polymerase conformation

TraR and its homolog DksA are bacterial proteins that regulate transcription initiation by binding directly to RNA polymerase (RNAP) rather than to promoter DNA. Effects of TraR mimic the combined effects of DksA and its cofactor ppGpp, but the structural basis for regulation by these factors remain...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Chen, James, Gopalkrishnan, Saumya, Chiu, Courtney, Chen, Albert Y, Campbell, Elizabeth A, Gourse, Richard L, Ross, Wilma, Darst, Seth A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2019
Konular:
Biochemistry and Chemical Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970531/
https://ncbi.nlm.nih.gov/pubmed/31841111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49375
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