Bromodomains and Extra-Terminal (BET) Inhibitor JQ1 Suppresses Proliferation of Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolysis

BACKGROUND: Acute lymphocytic leukemia (ALL) is a common blood cancer which induces high mortality in children. Bromodomains and extra-terminal (BET) protein inhibitors, such as JQ1 and ARV-825, are promising cancer therapeutic agents that can be used by targeting c-Myc. A recent work reported that...

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Vydáno v:Med Sci Monit
Hlavní autoři: Zhang, Meng-Yi, Liu, Sheng-Li, Huang, Wen-Li, Tang, Da-Bin, Zheng, Wei-Wei, Zhou, Neng, Zhou, Hang, Abudureheman, Tuersunayi, Tang, Zhong-Hua, Zhou, Bin-Bing S., Duan, Cai-Wen
Médium: Artigo
Jazyk:Inglês
Vydáno: International Scientific Literature, Inc. 2020
Témata:
Lab/In Vitro Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165247/
https://ncbi.nlm.nih.gov/pubmed/32266878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.923411
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