An evolutionary insertion in the Mxra8 receptor binding site confers resistance to alphavirus infection and pathogenesis

Alphaviruses are emerging, mosquito-transmitted RNA viruses with poorly understood cellular tropism and species selectivity. Mxra8 is an entry receptor for multiple alphaviruses including chikungunya virus (CHIKV). We discovered that while expression of mouse, rat, chimpanzee, dog, horse, goat, shee...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Kim, Arthur S., Zimmerman, Ofer, Fox, Julie M., Nelson, Christopher A., Basore, Katherine, Zhang, Rong, Durnell, Lorellin, Desai, Chandni, Bullock, Christopher, Deem, Sharon L., Oppenheimer, Jonas, Shapiro, Beth, Wang, Ting, Cherry, Sara, Coyne, Carolyn B., Handley, Scott A., Landis, Michael J., Fremont, Daved H., Diamond, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163869/
https://ncbi.nlm.nih.gov/pubmed/32075743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.01.008
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