Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression

Rationale: KRAS is one of the most frequently mutated oncogenes in cancers. The protein's picomolar affinity for GTP/GDP and smooth protein structure resulting in the absence of known allosteric regulatory sites makes its genomic-level activating mutations a difficult but attractive target. Met...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Theranostics
Prif Awduron: Gao, Qianqian, Ouyang, Wenjie, Kang, Bin, Han, Xu, Xiong, Ying, Ding, Renpeng, Li, Yijian, Wang, Fei, Huang, Lei, Chen, Lei, Wang, Dan, Dong, Xuan, Zhang, Zhao, Li, Yanshan, Ze, Baichen, Hou, Yong, Yang, Huanming, Ma, Yuanyuan, Gu, Ying, Chao, Cheng-Chi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ivyspring International Publisher 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163449/
https://ncbi.nlm.nih.gov/pubmed/32308773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.42325
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg