Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression

Rationale: KRAS is one of the most frequently mutated oncogenes in cancers. The protein's picomolar affinity for GTP/GDP and smooth protein structure resulting in the absence of known allosteric regulatory sites makes its genomic-level activating mutations a difficult but attractive target. Met...

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Udgivet i:Theranostics
Main Authors: Gao, Qianqian, Ouyang, Wenjie, Kang, Bin, Han, Xu, Xiong, Ying, Ding, Renpeng, Li, Yijian, Wang, Fei, Huang, Lei, Chen, Lei, Wang, Dan, Dong, Xuan, Zhang, Zhao, Li, Yanshan, Ze, Baichen, Hou, Yong, Yang, Huanming, Ma, Yuanyuan, Gu, Ying, Chao, Cheng-Chi
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163449/
https://ncbi.nlm.nih.gov/pubmed/32308773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.42325
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