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Selective disruption of an oncogenic mutant allele by CRISPR/Cas9 induces efficient tumor regression

Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly inter...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Koo, Taeyoung, Yoon, A-Rum, Cho, Hee-Yeon, Bae, Sangsu, Yun, Chae-Ok, Kim, Jin-Soo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570104/
https://ncbi.nlm.nih.gov/pubmed/28575452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx490
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