Understanding the drug exposure–response relationship of bedaquiline to predict efficacy for novel dosing regimens in the treatment of multidrug‐resistant tuberculosis

AIMS: To externally validate an earlier characterized relationship between bedaquiline exposure and decline in bacterial load in a more difficult‐to‐treat patient population, and to explore the performances of alternative dosing regimens through simulations. METHODS: The bedaquiline exposure–respons...

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Bibliografische gegevens
Gepubliceerd in:Br J Clin Pharmacol
Hoofdauteurs: Tanneau, Lénaïg, Karlsson, Mats O., Svensson, Elin M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7163373/
https://ncbi.nlm.nih.gov/pubmed/31840278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14199
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