Model-Based Estimates of the Effects of Efavirenz on Bedaquiline Pharmacokinetics and Suggested Dose Adjustments for Patients Coinfected with HIV and Tuberculosis

Safe, effective concomitant treatment regimens for tuberculosis (TB) and HIV infection are urgently needed. Bedaquiline (BDQ) is a promising new anti-TB drug, and efavirenz (EFV) is a commonly used antiretroviral. Due to EFV's induction of cytochrome P450 3A4, the metabolic enzyme responsible f...

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Detalhes bibliográficos
Main Authors: Svensson, Elin M., Aweeka, Francesca, Park, Jeong-Gun, Marzan, Florence, Dooley, Kelly E., Karlsson, Mats O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716161/
https://ncbi.nlm.nih.gov/pubmed/23571542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00191-13
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