Novel M(2)‐selective, G(i)‐biased agonists of muscarinic acetylcholine receptors

BACKGROUND AND PURPOSE: More than 30% of currently marketed medications act via GPCRs. Thus, GPCRs represent one of the most important pharmacotherapeutic targets. In contrast to traditional agonists activating multiple signalling pathways, agonists activating a single signalling pathway represent a...

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發表在:Br J Pharmacol
Main Authors: Randáková, Alena, Nelic, Dominik, Ungerová, Dana, Nwokoye, Peter, Su, Qiwen, Doležal, Vladimír, El‐Fakahany, Esam E., Boulos, John, Jakubík, Jan
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7161557/
https://ncbi.nlm.nih.gov/pubmed/31910288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14970
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