Allosteric regulation accompanied by oligomeric state changes of Trypanosoma brucei GMP reductase through cystathionine-β-synthase domain

Guanosine 5′-monophosphate reductase (GMPR) is involved in the purine salvage pathway and is conserved throughout evolution. Nonetheless, the GMPR of Trypanosoma brucei (TbGMPR) includes a unique structure known as the cystathionine-β-synthase (CBS) domain, though the role of this domain is not full...

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Pubblicato in:Nat Commun
Autori principali: Imamura, Akira, Okada, Tetsuya, Mase, Hikaru, Otani, Takuya, Kobayashi, Tomoka, Tamura, Manatsu, Kubata, Bruno Kilunga, Inoue, Katsuaki, Rambo, Robert P., Uchiyama, Susumu, Ishii, Kentaro, Nishimura, Shigenori, Inui, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160140/
https://ncbi.nlm.nih.gov/pubmed/32296055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15611-3
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