Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals

The metabolic pathway of purine nucleotides in parasitic protozoa is a potent drug target for treatment of parasitemia. Guanosine 5’-monophosphate reductase (GMPR), which catalyzes the deamination of guanosine 5’-monophosphate (GMP) to inosine 5’-monophosphate (IMP), plays an important role in the i...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Bessho, Tomoaki, Okada, Tetsuya, Kimura, Chihiro, Shinohara, Takahiro, Tomiyama, Ai, Imamura, Akira, Kuwamura, Mitsuru, Nishimura, Kazuhiko, Fujimori, Ko, Shuto, Satoshi, Ishibashi, Osamu, Kubata, Bruno Kilunga, Inui, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4701174/
https://ncbi.nlm.nih.gov/pubmed/26731263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004339
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