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Allosteric modulation of protein oligomerization: an emerging approach to drug design
Many disease-related proteins are in equilibrium between different oligomeric forms. The regulation of this equilibrium plays a central role in maintaining the activity of these proteins in vitro and in vivo. Modulation of the oligomerization equilibrium of proteins by molecules that bind preferenti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982530/ https://ncbi.nlm.nih.gov/pubmed/24790978 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2014.00009 |
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