Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

The involvement of host immunity in the gut microbiota-mediated colonization resistance to Clostridioides difficile infection (CDI) is incompletely understood. Here, we show that interleukin (IL)-22, induced by colonization of the gut microbiota, is crucial for the prevention of CDI in human microbi...

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Publicado no:Nat Med
Main Authors: Nagao-Kitamoto, Hiroko, Leslie, Jhansi L., Kitamoto, Sho, Jin, Chunsheng, Thomsson, Kristina A., Gillilland, Merritt G., Kuffa, Peter, Goto, Yoshiyuki, Jenq, Robert R., Ishii, Chiharu, Hirayama, Akiyoshi, Seekatz, Anna M., Martens, Eric C., Eaton, Kathryn A., Kao, John Y., Fukuda, Shinji, Higgins, Peter D. R., Karlsson, Niclas G., Young, Vincent B., Kamada, Nobuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160049/
https://ncbi.nlm.nih.gov/pubmed/32066975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0764-0
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