O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5

In this study, we demonstrated an essential function of the hexosamine biosynthesis pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in influenza A virus (IAV)–induced cytokine storm. O-GlcNAc transferase (OGT), a key enzyme for protein O-GlcNAcylation, mediated IAV-induc...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Wang, Qiming, Fang, Peining, He, Rui, Li, Mengqi, Yu, Haisheng, Zhou, Li, Yi, Yu, Wang, Fubing, Rong, Yuan, Zhang, Yi, Chen, Aidong, Peng, Nanfang, Lin, Yong, Lu, Mengji, Zhu, Ying, Peng, Guoping, Rao, Liqun, Liu, Shi
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7159909/
https://ncbi.nlm.nih.gov/pubmed/32494619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz7086
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