Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (PLK1). Here we describe how this phosphorylation contributes to the control of mitosis. We identify a conserv...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ehlén, Åsa, Martin, Charlotte, Miron, Simona, Julien, Manon, Theillet, François-Xavier, Ropars, Virginie, Sessa, Gaetana, Beaurepere, Romane, Boucherit, Virginie, Duchambon, Patricia, El Marjou, Ahmed, Zinn-Justin, Sophie, Carreira, Aura
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156385/
https://ncbi.nlm.nih.gov/pubmed/32286328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15689-9
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