BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair

The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA‐RNA hybrids, a known source of genome instability. However, the specific role of BRCA2 on these structures remains poorly underst...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Sessa, Gaetana, Gómez‐González, Belén, Silva, Sonia, Pérez‐Calero, Carmen, Beaurepere, Romane, Barroso, Sonia, Martineau, Sylvain, Martin, Charlotte, Ehlén, Åsa, Martínez, Juan S, Lombard, Bérangère, Loew, Damarys, Vagner, Stephan, Aguilera, Andrés, Carreira, Aura
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013831/
https://ncbi.nlm.nih.gov/pubmed/33634895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106018
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados