BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair

The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA‐RNA hybrids, a known source of genome instability. However, the specific role of BRCA2 on these structures remains poorly underst...

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Veröffentlicht in:EMBO J
Hauptverfasser: Sessa, Gaetana, Gómez‐González, Belén, Silva, Sonia, Pérez‐Calero, Carmen, Beaurepere, Romane, Barroso, Sonia, Martineau, Sylvain, Martin, Charlotte, Ehlén, Åsa, Martínez, Juan S, Lombard, Bérangère, Loew, Damarys, Vagner, Stephan, Aguilera, Andrés, Carreira, Aura
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013831/
https://ncbi.nlm.nih.gov/pubmed/33634895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106018
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