Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-like kinase 1 (PLK1). Here we describe how this phosphorylation contributes to the control of mitosis. We identify a conserv...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Ehlén, Åsa, Martin, Charlotte, Miron, Simona, Julien, Manon, Theillet, François-Xavier, Ropars, Virginie, Sessa, Gaetana, Beaurepere, Romane, Boucherit, Virginie, Duchambon, Patricia, El Marjou, Ahmed, Zinn-Justin, Sophie, Carreira, Aura
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156385/
https://ncbi.nlm.nih.gov/pubmed/32286328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15689-9
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