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The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis
Apolipoprotein E (ApoE) is an important modifier of Alzheimer’s disease (AD) pathogenesis, and its abundance has been linked to the clearance of β-amyloid (Aβ) in the brain. The pathways that control the clearance of ApoE in the brain are incompletely understood. We report that Idol, an E3 ubiquitin...
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| Yayımlandı: | Sci Transl Med |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7153735/ https://ncbi.nlm.nih.gov/pubmed/26582899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad1904 |
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