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The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood. Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein levels...

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Publicat a:eLife
Autors principals: Gao, Jie, Marosi, Mate, Choi, Jinkuk, Achiro, Jennifer M, Kim, Sangmok, Li, Sandy, Otis, Klara, Martin, Kelsey C, Portera-Cailliau, Carlos, Tontonoz, Peter
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593505/
https://ncbi.nlm.nih.gov/pubmed/28891791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.29178
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