Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway modulation was demonstrated in vivo, which enabled...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Parr, Brendan T., Pastor, Richard, Sellers, Benjamin D., Pei, Zhonghua, Jaipuri, Firoz A., Castanedo, Georgette M., Gazzard, Lewis, Kumar, Sanjeev, Li, Xiaokai, Liu, Wen, Mendonca, Rohan, Pavana, Roheeth K., Potturi, Hima, Shao, Cheng, Velvadapu, Venkata, Waldo, Jesse P., Wu, Guosheng, Yuen, Po-wai, Zhang, Zuhui, Zhang, Yamin, Harris, Seth F., Oh, Angela J., DiPasquale, Antonio, Dement, Kevin, La, Hank, Goon, Leanne, Gustafson, Amy, VanderPorten, Erica C., Mautino, Mario R., Liu, Yichin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153281/
https://ncbi.nlm.nih.gov/pubmed/32292562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00004
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