Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET(V804M) Kinase

[Image: see text] A combination of focused library and virtual screening, hit expansion, and rational design has resulted in the development of a series of inhibitors of RET(V804M) kinase, the anticipated drug-resistant mutant of RET kinase. These agents do not inhibit the wild type (wt) isoforms of...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Newton, Rebecca, Waszkowycz, Bohdan, Seewooruthun, Chitra, Burschowsky, Daniel, Richards, Mark, Hitchin, Samantha, Begum, Habiba, Watson, Amanda, French, Eleanor, Hamilton, Niall, Jones, Stuart, Lin, Li-Ying, Waddell, Ian, Echalier, Aude, Bayliss, Richard, Jordan, Allan M., Ogilvie, Donald
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153033/
https://ncbi.nlm.nih.gov/pubmed/32292556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00615
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