Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors

[Image: see text] Apoptosis signal-regulating kinase 1 (ASK1) is a key mediator in the apoptotic and inflammatory cellular stress response. To investigate the therapeutic value of modulating this pathway in neurological disease, we have completed medicinal chemistry studies to identify novel CNS-pen...

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Publicat a:ACS Med Chem Lett
Autors principals: Xin, Zhili, Himmelbauer, Martin K., Jones, J. Howard, Enyedy, Istvan, Gilfillan, Rab, Hesson, Thomas, King, Kristopher, Marcotte, Douglas J., Murugan, Paramasivam, Santoro, Joseph C., Gonzalez-Lopez de Turiso, Felix
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153032/
https://ncbi.nlm.nih.gov/pubmed/32292554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00611
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