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Biochemical characterization of acyl activating enzymes for side chain moieties of Taxol and its analogs

Taxol (paclitaxel) is a very widely used anticancer drug, but its commercial sources mainly consist of stripped bark or suspension cultures of members of the plant genus Taxus. Taxol accumulates as part of a complex mixture of chemical analogs, termed taxoids, which complicates its production in pur...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Srividya, Narayanan, Lange, Iris, Hartmann, Michael, Li, Qunrui, Mirzaei, Maryam, Lange, Bernd Markus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152758/
https://ncbi.nlm.nih.gov/pubmed/32086380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012663
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