The luminescent HiBiT peptide enables selective quantitation of G protein–coupled receptor ligand engagement and internalization in living cells

G protein–coupled receptors (GPCRs) are prominent targets to new therapeutics for a range of diseases. Comprehensive assessments of their cellular interactions with bioactive compounds, particularly in a kinetic format, are imperative to the development of drugs with improved efficacy. Hence, we dev...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Boursier, Michelle E., Levin, Sergiy, Zimmerman, Kris, Machleidt, Thomas, Hurst, Robin, Butler, Braeden L., Eggers, Christopher T., Kirkland, Thomas A., Wood, Keith V., Friedman Ohana, Rachel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2020
Konular:
Methods and Resources
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152755/
https://ncbi.nlm.nih.gov/pubmed/32107310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011952
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