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Mechanism of TRPM2 channel gating revealed by cryo-EM
Transient receptor potential melastatin 2 (TRPM2) is a non-selective cation channel that allows Ca(2+) influx across the plasma membrane and efflux from lysosomes upon opening. TRPM2 is best known as a biosensor of reactive oxygen species (ROS), which mediates some of the body’s responses to oxidati...
Uloženo v:
| Vydáno v: | FEBS J |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7151886/ https://ncbi.nlm.nih.gov/pubmed/31144442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14939 |
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