Mechanism of pharmacochaperoning in a mammalian K(ATP) channel revealed by cryo-EM

ATP-sensitive potassium (K(ATP)) channels composed of a pore-forming Kir6.2 potassium channel and a regulatory ABC transporter sulfonylurea receptor 1 (SUR1) regulate insulin secretion in pancreatic β-cells to maintain glucose homeostasis. Mutations that impair channel folding or assembly prevent ce...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Martin, Gregory M, Sung, Min Woo, Yang, Zhongying, Innes, Laura M, Kandasamy, Balamurugan, David, Larry L, Yoshioka, Craig, Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Structural Biology and Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699824/
https://ncbi.nlm.nih.gov/pubmed/31343405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46417
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