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Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating
K(ATP) channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas. Here, we used cryo-EM to elucidate structural basis of channel assembly...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344670/ https://ncbi.nlm.nih.gov/pubmed/28092267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24149 |
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