Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

K(ATP) channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas. Here, we used cryo-EM to elucidate structural basis of channel assembly...

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Vydáno v:eLife
Hlavní autoři: Martin, Gregory M, Yoshioka, Craig, Rex, Emily A, Fay, Jonathan F, Xie, Qing, Whorton, Matthew R, Chen, James Z, Shyng, Show-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344670/
https://ncbi.nlm.nih.gov/pubmed/28092267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24149
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