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Structures and gating mechanism of human TRPM2
Transient receptor potential (TRP) melastatin 2 (TRPM2) is a cation channel associated with numerous diseases. It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)–ribose (ADPR), and both ADPR and calcium (Ca(2+)) are required for TRPM2 activation. H...
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| Publicado no: | Science |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6459600/ https://ncbi.nlm.nih.gov/pubmed/30467180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav4809 |
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