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Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel

The transient receptor potential melastatin 2 (TRPM2) channel plays a key role in redox sensation in many cell types. Channel activation requires binding of both ADP-ribose (ADPR) and Ca(2+). The recently published TRPM2 structures from Danio rerio in the ligand-free and the ADPR/Ca(2+)-bound condit...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Yin, Ying, Wu, Mengyu, Hsu, Allen L., Borschel, William F., Borgnia, Mario J., Lander, Gabriel C., Lee, Seok-Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702222/
https://ncbi.nlm.nih.gov/pubmed/31431622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11733-5
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