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Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel
The transient receptor potential melastatin 2 (TRPM2) channel plays a key role in redox sensation in many cell types. Channel activation requires binding of both ADP-ribose (ADPR) and Ca(2+). The recently published TRPM2 structures from Danio rerio in the ligand-free and the ADPR/Ca(2+)-bound condit...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6702222/ https://ncbi.nlm.nih.gov/pubmed/31431622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11733-5 |
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