αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish

We report the discovery and functional characterization of αM-Conotoxin MIIIJ, a peptide from the venom of the fish-hunting cone snail Conus magus. Injections of αM-MIIIJ induced paralysis in goldfish (Carassius auratus) but not mice. Intracellular recording from skeletal muscles of fish (C. auratus...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: Rybin, Matthew J., O’Brien, Henrik, Ramiro, Iris Bea L., Azam, Layla, McIntosh, J. Michael, Olivera, Baldomero M., Safavi-Hemami, Helena, Yoshikami, Doju
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150935/
https://ncbi.nlm.nih.gov/pubmed/32245200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12030197
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