Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine the concentrations of enasidenib in rat plasma. When preparing the sample, we used acetonitrile for protein precipitation. The gradient elution method was use...

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Detalles Bibliográficos
Publicado en:Int J Anal Chem
Autores principales: Li, Shuang-long, Zhu, Yong-liang, Zhang, Yi, Liu, Shu-han, Wang, Xiang-die, Qiu, Xiang-jun
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150726/
https://ncbi.nlm.nih.gov/pubmed/32292480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5084127
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