Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine the concentrations of enasidenib in rat plasma. When preparing the sample, we used acetonitrile for protein precipitation. The gradient elution method was use...

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Bibliographic Details
Published in:Int J Anal Chem
Main Authors: Li, Shuang-long, Zhu, Yong-liang, Zhang, Yi, Liu, Shu-han, Wang, Xiang-die, Qiu, Xiang-jun
Format: Artigo
Language:Inglês
Published: Hindawi 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150726/
https://ncbi.nlm.nih.gov/pubmed/32292480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5084127
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