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Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application

In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine the concentrations of enasidenib in rat plasma. When preparing the sample, we used acetonitrile for protein precipitation. The gradient elution method was use...

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Detalhes bibliográficos
Publicado no:Int J Anal Chem
Main Authors: Li, Shuang-long, Zhu, Yong-liang, Zhang, Yi, Liu, Shu-han, Wang, Xiang-die, Qiu, Xiang-jun
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150726/
https://ncbi.nlm.nih.gov/pubmed/32292480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5084127
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