Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study

A new, simple, and sensitive ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for quantification of fruquintinib was established to assess the pharmacokinetics of fruquintinib in the rat. The internal standard working solution was added to the plasma sample for ext...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Drug Des Devel Ther
Main Authors: Mei, Yi-Bin, Luo, Shun-Bin, Ye, Ling-Yan, Zhang, Qiang, Guo, Jing, Qiu, Xiang-Jun, Xie, Sai-Li
Format: Artigo
Jezik:Inglês
Izdano: Dove 2019
Teme:
Methodology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699497/
https://ncbi.nlm.nih.gov/pubmed/31616134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S199362
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