DIFFERENTIAL EXTRACELLULAR, BUT SIMILAR INTRACELLULAR, DISPOSITION OF TWO TENOFOVIR FORMULATIONS IN THE MALE GENITAL TRACT

BACKGROUND: The male genital tract (MGT) is a viral sanctuary and likely HIV reservoir; understanding MGT pharmacokinetics (PK) of antiretrovirals (ARVs) used for curative strategies is critical to eradication and cure. Tenofovir alafenamide (TAF) is a tenofovir (TFV) formulation designed to maximiz...

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Veröffentlicht in:Antivir Ther
Hauptverfasser: DUMOND, JULIE B., GREENE, STEPHEN A., PRINCE, HEATHER M.A., CHEN, JINGXIAN, MAAS, BRIAN L., SYKES, CRAIG, SCHAUER, AMANDA P., BLAKE, KIMBERLY, NELSON, JULIE A.E., GAY, CYNTHIA L., KASHUBA, ANGELA D.M., COHEN, MYRON S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7147147/
https://ncbi.nlm.nih.gov/pubmed/30375984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP3277
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