A Chemical Biology Approach to Probing the Folding Pathways of the Inhibitory Cystine Knot (ICK) Peptide ProTx-II

Peptide toxins that adopt the inhibitory cystine knot (ICK) scaffold have very stable three-dimensional structures as a result of the conformational constraints imposed by the configuration of the three disulfide bonds that are the hallmark of this fold. Understanding the oxidative folding pathways...

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Bibliographische Detailangaben
Veröffentlicht in:Front Chem
Hauptverfasser: McCarthy, Stephen, Robinson, Jenna, Thalassinos, Konstantinos, Tabor, Alethea B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145985/
https://ncbi.nlm.nih.gov/pubmed/32309273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.00228
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