Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo

RNA structures that impede ribosome binding or subsequent scanning of the 5′-untranslated region (5′-UTR) for the AUG initiation codon reduce translation efficiency. Yeast DEAD-box RNA helicase Ded1 appears to promote translation by resolving 5′-UTR structures, but whether its paralog, Dbp1, perform...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Sen, Neelam Dabas, Gupta, Neha, K. Archer, Stuart, Preiss, Thomas, Lorsch, Jon R, Hinnebusch, Alan G
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
RNA and RNA-protein complexes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145680/
https://ncbi.nlm.nih.gov/pubmed/31299079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz595
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