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Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A

DEAD-box RNA helicases eIF4A and Ded1 are believed to promote translation initiation by resolving mRNA secondary structures that impede ribosome attachment at the mRNA 5′ end or subsequent scanning of the 5′ UTR, but whether they perform unique or overlapping functions in vivo is poorly understood....

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Sen, Neelam Dabas, Zhou, Fujun, Ingolia, Nicholas T., Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510003/
https://ncbi.nlm.nih.gov/pubmed/26122911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.191601.115
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